Hba-a1^tm1Shs
Targeted Allele Detail

Summary

• Symbol: Hba-a1^tm1Shs
• Name: hemoglobin alpha, adult chain 1; targeted mutation 1, Takuji Shirasawa
• MGI ID: MGI:2451238
• Synonyms: alpha^Titu
• Gene: Hba-a1 Location: Chr11:32233672-32234486 bp, + strand Genetic Position: Chr11, 18.86 cM
• Alliance: Hba-a1^tm1Shs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81902
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: A transition point mutation was introduced at codon 94 via site directed mutagenesis, resulting in an Asp to Asn substitution (D94N) at the alpha/beta interface of the hemoglobin molecule. An intronic floxed neo cassette was included downstream of the coding region. (J:81902)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hba-a1 Mutation: 3 strains or lines available

References

• Original: J:81902 Shirasawa T, et al., Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity. J Biol Chem. 2003 Feb 14;278(7):5035-43
• All: 1 reference(s)