Fancl^tm1Ceb
Targeted Allele Detail

Summary

• Symbol: Fancl^tm1Ceb
• Name: Fanconi anemia, complementation group L; targeted mutation 1, Colin E Bishop
• MGI ID: MGI:2451263
• Synonyms: Pog-
• Gene: Fancl Location: Chr11:26337084-26421883 bp, + strand Genetic Position: Chr11, 15.85 cM, cytoband A2-A3
• Alliance: Fancl^tm1Ceb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80424
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The endogenous allele was disrupted by the insertion of a vector containing exons 9 through 13, selection genes, and a 300 bp gap in intron 11. Homologous recombination of the vector results in double stranded gap repair, producing an allele in which exon 13 is followed by the selection genes and duplicates of exons 9 through 13. Transcript was undetected in homozygous mutant mice by RT-PCR analysis of gonad and spleen tissue. Expression of Vrk2, the adjacent locus, was unaffected. (J:80424)

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancl Mutation: 29 strains or lines available

References

• Original: J:80424 Agoulnik AI, et al., A novel gene, Pog, is necessary for primordial germ cell proliferation in the mouse and underlies the germ cell deficient mutation, gcd. Hum Mol Genet. 2002 Nov 15;11(24):3047-53
• All: 3 reference(s)