Atp1a1^tm1Ling
Targeted Allele Detail

Summary

• Symbol: Atp1a1^tm1Ling
• Name: ATPase, Na+/K+ transporting, alpha 1 polypeptide; targeted mutation 1, Jerry B Lingrel
• MGI ID: MGI:2451290
• Synonyms: alpha1^-
• Gene: Atp1a1 Location: Chr3:101483535-101512000 bp, - strand Genetic Position: Chr3, 44.3 cM, cytoband F3
• Alliance: Atp1a1^tm1Ling page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55191
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 15 through 18 were replaced with an hprt cassette via homologous recombination. Both alpha 1 transcript and protein levels were reduced by ~40% in heterozygous mutant hearts. An aberrant alpha 1 transcript was detected but was not expected to produce a functional protein. (J:55191)

Expression

In Mice Carrying this Mutation:	5 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1a1 Mutation: 61 strains or lines available

References

• Original: J:55191 James PF, et al., Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell. 1999 May;3(5):555-63
• All: 16 reference(s)