Atp1a2^tm2Ling
Targeted Allele Detail

Summary

• Symbol: Atp1a2^tm2Ling
• Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 2, Jerry B Lingrel
• MGI ID: MGI:2451291
• Synonyms: alpha2^-
• Gene: Atp1a2 Location: Chr1:172099276-172125631 bp, - strand Genetic Position: Chr1, 79.6 cM
• Alliance: Atp1a2^tm2Ling page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55191
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of an hprt cassette into exon 4 resulted in an alpha 2 isoform specific disruption. Both alpha 2 transcript and protein levels were reduced by ~50% in heterozygous mutant hearts. An aberrant alpha 2 transcript was detected but was not expected to produce a functional protein. (J:55191)

Expression

In Mice Carrying this Mutation:	39 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1a2 Mutation: 62 strains or lines available

References

• Original: J:55191 James PF, et al., Identification of a specific role for the Na,K-ATPase alpha 2 isoform as a regulator of calcium in the heart. Mol Cell. 1999 May;3(5):555-63
• All: 13 reference(s)