Wasf1^tm1Jsco
Targeted Allele Detail

Summary

• Symbol: Wasf1^tm1Jsco
• Name: WASP family, member 1; targeted mutation 1, John D Scott
• MGI ID: MGI:2451310
• Synonyms: wave^-
• Gene: Wasf1 Location: Chr10:40759476-40814565 bp, + strand Genetic Position: Chr10, 22.07 cM
• Alliance: Wasf1^tm1Jsco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81968
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was replaced with a cassette containing both uracil- and neomycin-resistance genes. The insertion deleted 95 bp, including the splice donor site of exon 4, and introduced a nonsense mutation at codon 175. Normal protein was undetected by Western blot analysis of homozygous mutant brain tissue. (J:81968)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Wasf1 Mutation: 50 strains or lines available

Notes

ES cell line = JSI-1.

References

• Original: J:81968 Soderling SH, et al., Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1723-8
• All: 4 reference(s)