Cbl^tm1Wlan
Targeted Allele Detail

Summary

• Symbol: Cbl^tm1Wlan
• Name: Casitas B-lineage lymphoma; targeted mutation 1, Wallace Langdon
• MGI ID: MGI:2451336
• Synonyms: E
• Gene: Cbl Location: Chr9:44054273-44145346 bp, - strand Genetic Position: Chr9, 24.72 cM
• Alliance: Cbl^tm1Wlan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81965
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: A transition point mutation resulted in a glycine to glutamic acid substitution at position 304 (G304E). The substitution is within the tyrosine kinase binding domain (TKB). (J:81965)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cbl Mutation: 59 strains or lines available

References

• Original: J:81965 Thien CB, et al., A mouse with a loss-of-function mutation in the c-Cbl TKB domain shows perturbed thymocyte signaling without enhancing the activity of the ZAP-70 tyrosine kinase. J Exp Med. 2003 Feb 17;197(4):503-13
• All: 1 reference(s)