Scn2b^tm1Isom
Targeted Allele Detail

Summary

• Symbol: Scn2b^tm1Isom
• Name: sodium channel, voltage-gated, type II, beta; targeted mutation 1, Lori L Isom
• MGI ID: MGI:2451362
• Synonyms: Beta2^-, Scn2b^tm1Lli
• Gene: Scn2b Location: Chr9:45029174-45041368 bp, + strand Genetic Position: Chr9, 24.84 cM
• Alliance: Scn2b^tm1Isom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82050
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3, which encode the mature protein, were replaced with a neo cassette inserted by homologous recombination. Neither transcript nor protein were detected by Northern and Western blot analyses of homozygous mutant brain tissues. (J:82050)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn2b Mutation: 14 strains or lines available

References

• Original: J:82050 Chen C, et al., Reduced sodium channel density, altered voltage dependence of inactivation, and increased susceptibility to seizures in mice lacking sodium channel beta 2-subunits. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17072-7
• All: 9 reference(s)