Neurog3^tm1(EGFP)Khk
Targeted Allele Detail

Summary

• Symbol: Neurog3^tm1(EGFP)Khk
• Name: neurogenin 3; targeted mutation 1, Klaus H Kaestner
• MGI ID: MGI:2651394
• Synonyms: Neurog3^EGFP, ngn3-, Ngn3-eGFP
• Gene: Neurog3 Location: Chr10:61968869-61970542 bp, + strand Genetic Position: Chr10, 32.35 cM, cytoband B4
• Alliance: Neurog3^tm1(EGFP)Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:77398
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin resistance cassette containing EGFP cDNA and lox sites flanking the PGK-neo sequence replaced the coding region. Confocal images detected EGFP expression in the glandular stomach of P3 heterozygous mutant mice, and not in the squamous epithelium of the forestomach. (J:77398)

Expression

In Mice Carrying this Mutation:	5 assay results 12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Neurog3 Mutation: 19 strains or lines available

References

• Original: J:77398 Lee CS, et al., Neurogenin 3 is essential for the proper specification of gastric enteroendocrine cells and the maintenance of gastric epithelial cell identity. Genes Dev. 2002 Jun 15;16(12):1488-97
• All: 35 reference(s)