Acvr1^tm1Vk
Targeted Allele Detail

Summary

• Symbol: Acvr1^tm1Vk
• Name: activin A receptor, type 1; targeted mutation 1, Vesa Kaartinen
• MGI ID: MGI:2651395
• Synonyms: Acvr1^flox, alk2, Alk2^fl, Alk2^FX
• Gene: Acvr1 Location: Chr2:58336450-58456840 bp, - strand Genetic Position: Chr2, 33.05 cM
• Alliance: Acvr1^tm1Vk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73148
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted into intron 6 and a loxP flanked neomycin selection cassette was inserted into intron 7. (J:73148)

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	28 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acvr1 Mutation: 44 strains or lines available

References

• Original: J:73148 Kaartinen V, et al., Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo. Genesis. 2001 Nov;31(3):126-9
• All: 37 reference(s)