Idua^tm1Efn
Targeted Allele Detail

Summary

• Symbol: Idua^tm1Efn
• Name: iduronidase, alpha-L; targeted mutation 1, Elizabeth F Neufeld
• MGI ID: MGI:2651471
• Gene: Idua Location: Chr5:108808197-108832423 bp, + strand Genetic Position: Chr5, 53.24 cM
• Alliance: Idua^tm1Efn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81974
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Exon 6 was disrupted by a neomycin selection cassette inserted by homologous recombination. (J:81974)

Disease models

Expression

In Structures Affected by this Mutation:

28 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Idua Mutation: 41 strains or lines available

References

• Original: J:81974 Ohmi K, et al., Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1902-7
• All: 22 reference(s)