Prkacb^tm2Gsm
Targeted Allele Detail

Summary

• Symbol: Prkacb^tm2Gsm
• Name: protein kinase, cAMP dependent, catalytic, beta; targeted mutation 2, G Stanley McKnight
• MGI ID: MGI:2651519
• Synonyms: C beta all^-
• Gene: Prkacb Location: Chr3:146435334-146518691 bp, - strand Genetic Position: Chr3, 72.28 cM, cytoband H3
• Alliance: Prkacb^tm2Gsm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78451
• Parent Cell Line: REK2 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis indicated an absence of all three isoforms in homozygous mutant mice. (J:78451)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkacb Mutation: 31 strains or lines available

References

• Original: J:78451 Howe DG, et al., Molecular and Behavioral Effects of a Null Mutation in All PKA Cbeta Isoforms. Mol Cell Neurosci. 2002 Jul;20(3):515-24
• All: 4 reference(s)