Gpx2^tm2Coh
Targeted Allele Detail

Summary

• Symbol: Gpx2^tm2Coh
• Name: glutathione peroxidase 2; targeted mutation 2, City of Hope, Beckman Research Institute
• MGI ID: MGI:2651587
• Synonyms: Gpx2^tm21Coh
• Gene: Gpx2 Location: Chr12:76839107-76842273 bp, - strand Genetic Position: Chr12, 33.73 cM
• Alliance: Gpx2^tm2Coh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63988
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exon 1 of the gene. Northern blots of total RNA isolated from the middle small intestine of homozygous mutant mice showed no detectable transcript of the targeted gene when probed with an exon 1 probe. This line was established simultaneously with Gpx2^tm1Coh.

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Gpx2^tm2Coh

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpx2 Mutation: 8 strains or lines available

References

• Original: J:63988 Esworthy RS, et al., Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage. Am J Physiol Gastrointest Liver Physiol. 2000 Aug;279(2):G426-36
• All: 14 reference(s)