Hoxd^tm4Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd^tm4Ddu
• Name: homeobox D cluster; targeted mutation 4, Denis Duboule
• MGI ID: MGI:2651622
• Synonyms: Hoxd^RXneo
• Gene: Hoxd Location: unknown Genetic Position: Chr2, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49264
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion
• Mutation details: A 261 bp fragment encompassing region X located in the intergenic sequence between Hoxd11 and Hoxd12 was deleted via homologous recombination of a targeting vector. In addition, the targeting vector also contained a floxed neo cassette 303 bp upstream of the deletion. (J:49264)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd Mutation: 0 strains or lines available

References

• Original: J:49264 Beckers J, et al., Genetic analysis of a conserved sequence in the HoxD complex: regulatory redundancy or limitations of the transgenic approach?. Dev Dyn. 1998 Sep;213(1):1-11
• All: 2 reference(s)