Pigr^tm1Fejo
Targeted Allele Detail

Summary

• Symbol: Pigr^tm1Fejo
• Name: polymeric immunoglobulin receptor; targeted mutation 1, Finn-Eirik Johansen
• MGI ID: MGI:2651657
• Synonyms: pIgR^-
• Gene: Pigr Location: Chr1:130754421-130779986 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband E3
• Alliance: Pigr^tm1Fejo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57987
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 3, which encodes the ligand binding extracellular receptor domain 1 (D1), was disrupted by a neomycin selection cassette inserted by homologous recombination. Two aberrant transcripts were identified in homozygous mutant mice by Northern blot analysis. Both transcripts lacked sequence encoding the extracellular binding domain and were not expected to bind the endogenous ligand. This targeting vector was also electroporated into ES cells derived from a C57BL/6 background to generated Pigr^tm1Rast. (J:57987)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Pigr Mutation: 60 strains or lines available

References

• Original: J:57987 Johansen FE, et al., Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice. J Exp Med. 1999 Oct 4;190(7):915-22
• All: 22 reference(s)