Pigr^tm1Rast
Targeted Allele Detail

Summary

• Symbol: Pigr^tm1Rast
• Name: polymeric immunoglobulin receptor; targeted mutation 1, Richard A Strugnell
• MGI ID: MGI:2651659
• Synonyms: pIgR^-
• Gene: Pigr Location: Chr1:130754421-130779986 bp, + strand Genetic Position: Chr1, 56.89 cM, cytoband E3
• Alliance: Pigr^tm1Rast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:81984
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The targeting vector used to generate Pigr^tm1Fejo was electroporated into ES cells derived from a C57BL/6 genetic background. Exon 3, which encodes the ligand binding extracellular receptor domain 1 (D1), was disrupted by a neomycin selection cassette inserted by homologous recombination. (J:81984)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Pigr Mutation: 60 strains or lines available

References

• Original: J:81984 Uren TK, et al., Role of the polymeric Ig receptor in mucosal B cell homeostasis. J Immunol. 2003 Mar 1;170(5):2531-9
• All: 9 reference(s)