a^t-2Gso
Spontaneous Allele Detail

Summary

• Symbol: a^t-2Gso
• Name: nonagouti; black and tan 2 Generoso
• MGI ID: MGI:2651789
• Synonyms: SB B+ T
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a^t-2Gso page

Mutation origin

• Strain of Origin: (SEC/RlGso a Tyrp1^b Tyr^c-ch x C57BL/RlGso a)F1

Mutation description

• Allele Type: Spontaneous
• Mutation: Viral insertion
• Mutation details: Characterization of this allele shows an insertion of DNA comprising a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats. The host intergration site is the same as for a^t-2Gso and A^w-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. (J:16984)
• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

Notes

This allele is recessive to A and A^w on the dorsum and dominant to all agouti alleles on the ventrum except for A^w from which it is indistinguishable (J:78801) .

References

• Original: J:3523 Bultman SJ, et al., Molecular characterization of the mouse agouti locus. Cell. 1992 Dec 24;71(7):1195-204
• All: 2 reference(s)