Erbb2^tm1Vrtn
Targeted Allele Detail

Summary

• Symbol: Erbb2^tm1Vrtn
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 1, Timothy Vartanian
• MGI ID: MGI:2651799
• Synonyms: erbB2^-
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^tm1Vrtn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing the exon encoding the essential transmembrane domain and portions of both the extracellular and cytomplasmic domains was replaced with a neomycin selection cassette inserted by homologous recombination. Western blot analysis detected reduced levels of protein in heterozygous embryos and no normal protein in homozygous embryos. (J:71775)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:71775 Park SK, et al., The erbB2 gene is required for the development of terminally differentiated spinal cord oligodendrocytes. J Cell Biol. 2001 Sep 17;154(6):1245-58
• All: 1 reference(s)