Lpl^tm1Bres
Targeted Allele Detail

Summary

• Symbol: Lpl^tm1Bres
• Name: lipoprotein lipase; targeted mutation 1, Jan L Breslow
• MGI ID: MGI:2651805
• Synonyms: L1, LPL^-
• Gene: Lpl Location: Chr8:69333207-69359584 bp, + strand Genetic Position: Chr8, 33.88 cM
• Alliance: Lpl^tm1Bres page

Gross pathology of Lpl^tm1Bres/Lpl^tm1Bres pups at 14-16 hours after birth

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30062
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing a portion of exon 1, including the start codon and signal sequence, and all of exon 2 was replaced with a neomycin selection cassette inserted by homologous recombination. Lipoprotein lipase activity was shown to be almost completely ablated in homozygous mutant mice. (J:30062)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lpl Mutation: 45 strains or lines available

References

• Original: J:30062 Weinstock PH, et al., Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest. 1995 Dec;96(6):2555-68
• All: 27 reference(s)