Wasl^tm1.1Sbs
Targeted Allele Detail

Summary

• Symbol: Wasl^tm1.1Sbs
• Name: WASP like actin nucleation promoting factor; targeted mutation 1.1, Scott B Snapper
• MGI ID: MGI:2651838
• Synonyms: N-WASP^-, Was^tm2.1Sbs
• Gene: Wasl Location: Chr6:24613804-24665008 bp, - strand Genetic Position: Chr6, 11.28 cM, cytoband A3
• Alliance: Wasl^tm1.1Sbs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72053
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed neo cassette that had replaced exon 2 was excised when mice carrying Wasl^tm1Sbs were mated with transgenic mice expressing cre recombinase in the germline. Normal protein was undetected by Western blot analysis of extracts obtained from homozygous mutant ES cells. (J:72053)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wasl Mutation: 39 strains or lines available

References

• Original: J:72053 Snapper SB, et al., N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct;3(10):897-904
• All: 7 reference(s)