Casp3^tm1Dsp
Targeted Allele Detail

Summary

• Symbol: Casp3^tm1Dsp
• Name: caspase 3; targeted mutation 1, David S Park
• MGI ID: MGI:2651856
• Synonyms: Casp3^tm1Mr1
• Gene: Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
• Alliance: Casp3^tm1Dsp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:63794
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by a lacZ-neo cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant spleens. (J:63794)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp3 Mutation: 33 strains or lines available

References

• Original: J:63794 Keramaris E, et al., Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage. Mol Cell Neurosci. 2000 Apr;15(4):368-79
• All: 10 reference(s)