Ptger2^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Ptger2^tm1Sna
• Name: prostaglandin E receptor 2 (subtype EP2); targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2651880
• Synonyms: EP(2)-, EP2-, Ptger2-
• Gene: Ptger2 Location: Chr14:45225652-45241277 bp, + strand Genetic Position: Chr14, 22.68 cM
• Alliance: Ptger2^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70534
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' portion of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of uterine tissue obtained from homozygous mutant females. (J:57482, J:70534)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptger2^tm1Sna

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptger2 Mutation: 31 strains or lines available

References

• Original: J:70534 Ushikubi F, et al., Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. 1998 Sep 17;395(6699):281-4
• All: 50 reference(s)