Ldb3^tm3Chen
Targeted Allele Detail

Summary

• Symbol: Ldb3^tm3Chen
• Name: LIM domain binding 3; targeted mutation 3, Ju Chen
• MGI ID: MGI:2652078
• Synonyms: Cypher3sKI
• Gene: Ldb3 Location: Chr14:34248560-34310639 bp, - strand Genetic Position: Chr14, 20.83 cM, cytoband B
• Alliance: Ldb3^tm3Chen page

Skeletal muscle abnormalities in Ldb3^tm2Chen/Ldb3^tm2Chen and Ldb3^tm3Chen/Ldb3^tm3Chen mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82141
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The endogenous gene was disrupted by the insertion of a cDNA encoding a 622 residue skeletal muscle isoform (Cypher3s in J:82141). The inserted sequence encodes the PDZ domain as well as the 3 carboxy terminal LIM domains. Expression of the inserted isoform was verified by Western blot analysis. (J:82141)

Expression

In Mice Carrying this Mutation:	1 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldb3 Mutation: 46 strains or lines available

References

• Original: J:82141 Huang C, et al., Characterization and in vivo functional analysis of splice variants of cypher. J Biol Chem. 2003 Feb 28;278(9):7360-5
• All: 2 reference(s)