Txk^tm1Pls
Targeted Allele Detail

Summary

• Symbol: Txk^tm1Pls
• Name: TXK tyrosine kinase; targeted mutation 1, Pamela L Schwartzberg
• MGI ID: MGI:2652126
• Synonyms: rlk^-
• Gene: Txk Location: Chr5:72853321-72910120 bp, - strand Genetic Position: Chr5, 38.44 cM
• Alliance: Txk^tm1Pls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:54449
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 6 was disrupted by the insertion of neo and multiple stop codons. Neither full length nor truncated protein products were detected by Western blot analyses of homozygous mutant lymphoid cell extracts. An splentocyte assay indicated an absence of endogenous kinase activity in homozygous mutant mice. (J:54449)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Txk Mutation: 40 strains or lines available

References

• Original: J:54449 Schaeffer EM, et al., Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity. Science. 1999 Apr 23;284(5414):638-41
• All: 16 reference(s)