H2-DMa^tm1Lkrl
Targeted Allele Detail

Summary

• Symbol: H2-DMa^tm1Lkrl
• Name: histocompatibility 2, class II, locus DMa; targeted mutation 1, Lars Karlsson
• MGI ID: MGI:2652160
• Synonyms: H2-DM^-, H2-M-
• Gene: H2-DMa Location: Chr17:34338667-34358075 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: H2-DMa^tm1Lkrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:31786
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by a neomycin selection cassette inserted by homologous recombination. H2-DM heterodimers were undetected in splenocytes obtained from homozygous mutant mice. (J:31786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H2-DMa Mutation: 27 strains or lines available

References

• Original: J:31786 Fung-Leung WP, et al., Antigen presentation and T cell development in H2-M-deficient mice. Science. 1996 Mar 1;271(5253):1278-81
• All: 6 reference(s)