Del(9Hspb2-Cryab)1Wawr
Targeted Allele Detail

Summary

• Symbol: Del(9Hspb2-Cryab)1Wawr
• Name: deletion, Chr 9, Eric F Wawrousek 1
• MGI ID: MGI:2652177
• Synonyms: alphaB-, alphaB/HSPB2^-, alphaBKO-168, Cryab^-, Cryab/Hspb2^tm1Wawr
• Gene: Del(9Hspb2-Cryab)1Wawr Location: unknown Genetic Position: Chr9, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72926
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(9Hspb2-Cryab)1Wawr involves 2 genes/genome features (Hspb2, Cryab) View all
• Mutation details: The insertion of a single targeting vector containing neo disrupted both Cryab and Hspb2. All of exons 1 and 2 and a portion of exon 3 were deleted at the Cryab locus. All of exon 1 and a portion of exon 2 were deleted at the Hspb2 locus. Cryab protein was undetected by Western blot analysis of homozgous mutant mice. Northern blot analysis of homozygous mutant heart and skeletal muscle showed an absence of Hspb2 mRNA. (J:72926)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(9Hspb2-Cryab)1Wawr Mutation: 0 strains or lines available

References

• Original: J:72926 Brady JP, et al., AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach. Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2924-34
• All: 37 reference(s)