Apex1^tm1Ecf
Targeted Allele Detail

Summary

• Symbol: Apex1^tm1Ecf
• Name: apurinic/apyrimidinic endonuclease 1; targeted mutation 1, Errol C Friedberg
• MGI ID: MGI:2652193
• Synonyms: Apex^-, HAP1^-
• Gene: Apex1 Location: Chr14:51162425-51164596 bp, + strand Genetic Position: Chr14, 26.3 cM, cytoband C3
• Alliance: Apex1^tm1Ecf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:70397
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing a portion of exon 2 and all of exons 3, 4, and 5 was replaced with a beta-geo cassette inserted by homologous recombination. Transcript and protein levels in heterozygous mutant mice were shown to be approximately half of those in wild-type mice by Northern and Western blot analysis. (J:70397)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apex1 Mutation: 16 strains or lines available

References

• Original: J:70397 Meira LB, et al., Heterozygosity for the mouse Apex gene results in phenotypes associated with oxidative stress. Cancer Res. 2001 Jul 15;61(14):5552-7
• All: 9 reference(s)