Hes7^tm1Kag
Targeted Allele Detail

Summary

• Symbol: Hes7^tm1Kag
• Name: hes family bHLH transcription factor 7; targeted mutation 1, Ryoichiro Kageyama
• MGI ID: MGI:2652222
• Synonyms: Hes7-, Hes7^tm1Rka
• Gene: Hes7 Location: Chr11:69011230-69014881 bp, + strand Genetic Position: Chr11, 42.38 cM
• Alliance: Hes7^tm1Kag page

Irregular sacral segmentation in Hes7^tm1Kag/Hes7^tm1Kag mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72325
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An IRES-lacZ-PGK-neomycin resistance cassette replaced most of the coding region. In situ hybridization studies of whole mount E9.5 embryos did not detect transcript in homozygous mutant embryos. (J:72325)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hes7 Mutation: 22 strains or lines available

References

• Original: J:72325 Bessho Y, et al., Dynamic expression and essential functions of Hes7 in somite segmentation. Genes Dev. 2001 Oct 15;15(20):2642-7
• All: 14 reference(s)