Pvalb^tm1Swal
Targeted Allele Detail

Summary

• Symbol: Pvalb^tm1Swal
• Name: parvalbumin; targeted mutation 1, Beat Schwaller
• MGI ID: MGI:2652272
• Synonyms: PV-
• Gene: Pvalb Location: Chr15:78075314-78090600 bp, - strand Genetic Position: Chr15, 36.93 cM, cytoband E
• Alliance: Pvalb^tm1Swal page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:53121
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A fragment encompassing a portion of exon 2 and all of exons 3 and 4 was replaced with a PGK-neo cassette inserted by homologous recombination. Approximately 85% (nt 25 to 304) of the coding region was deleted. No protein was detected by Western blot analysis of various skelelal muscle tissue samples obtained from homozygous mutant mice. (J:53121)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pvalb Mutation: 29 strains or lines available

References

• Original: J:53121 Schwaller B, et al., Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice. Am J Physiol. 1999 Feb;276(2 Pt 1):C395-403
• All: 31 reference(s)