Sod3^tm1Mrkl
Targeted Allele Detail

Summary

• Symbol: Sod3^tm1Mrkl
• Name: superoxide dismutase 3, extracellular; targeted mutation 1, Stefan L Marklund
• MGI ID: MGI:2652386
• Synonyms: ecSOD^-, EC-SOD^-
• Gene: Sod3 Location: Chr5:52521146-52527080 bp, + strand Genetic Position: Chr5, 27.92 cM
• Alliance: Sod3^tm1Mrkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:26851
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Sequence encoding the active site of the protein was disrupted by the insertion of a neomycin selection cassette. Superoxide dismutase activity was undetected in plasma obtained from homozygous mutant mice. (J:26851)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sod3 Mutation: 13 strains or lines available

References

• Original: J:26851 Carlsson LM, et al., Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6264-8
• All: 49 reference(s)