Gp5^tm1Drp
Targeted Allele Detail

Summary

• Symbol: Gp5^tm1Drp
• Name: glycoprotein 5 platelet; targeted mutation 1, David R Phillips
• MGI ID: MGI:2652408
• Synonyms: GP V -
• Gene: Gp5 Location: Chr16:30126503-30129597 bp, - strand Genetic Position: Chr16, 21.26 cM, cytoband B2
• Alliance: Gp5^tm1Drp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58516
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The entire coding region was replaced with a neomycin selection cassette inserted by homologous recombination. FACS analysis indicated an absence of the endogenous protein on the surface of platelets obtained from homozygous mutant mice. Western blot analysis of platelet lysates confirmed the lack of protein in homozogotes. (J:58516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gp5 Mutation: 17 strains or lines available

References

• Original: J:58516 Ramakrishnan V, et al., Increased thrombin responsiveness in platelets from mice lacking glycoprotein V. Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13336-41
• All: 2 reference(s)