Zfp36^tm1Pjb
Targeted Allele Detail

Summary

• Symbol: Zfp36^tm1Pjb
• Name: zinc finger protein 36; targeted mutation 1, Perry J Blackshear
• MGI ID: MGI:2652418
• Synonyms: TTP(-), TTP^-
• Gene: Zfp36 Location: Chr7:28076208-28078680 bp, - strand Genetic Position: Chr7, 16.72 cM
• Alliance: Zfp36^tm1Pjb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:33986
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was disrupted by the insertion of a neomycin selection cassette. Multiple stop codons were generated upstream of sequence encoding two putative zinc fingers. Northern blot analysis showed an absence of normal transcript and identified an aberrant transcript containing neo. Neither normal nor truncated protein was detected by Western blot analysis of MEFs derived from homozygous mutant mice. (J:33986)

Disease models

Expression

In Mice Carrying this Mutation:	52018 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Zfp36 Mutation: 19 strains or lines available

References

• Original: J:33986 Taylor GA, et al., A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity. 1996 May;4(5):445-54
• All: 52 reference(s)