Plcb1^tm1Hssh
Targeted Allele Detail

Summary

• Symbol: Plcb1^tm1Hssh
• Name: phospholipase C, beta 1; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2652485
• Synonyms: PLC-beta1^-, PLCBeta1^-
• Gene: Plcb1 Location: Chr2:134628084-135317178 bp, + strand Genetic Position: Chr2, 65.66 cM
• Alliance: Plcb1^tm1Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:43077
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The exon encoding amino acids 50 through 82 was disrupted by a neomycin selection cassette inserted by homologous recombination. (J:43077)

Disease models

Expression

In Mice Carrying this Mutation:	42 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcb1 Mutation: 71 strains or lines available

References

• Original: J:43077 Kim D, et al., Phospholipase C isozymes selectively couple to specific neurotransmitter receptors. Nature. 1997 Sep 18;389(6648):290-3
• All: 26 reference(s)