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Ikbkbtm2.1Cgn
Targeted Allele Detail
Summary
Symbol: Ikbkbtm2.1Cgn
Name: inhibitor of kappaB kinase beta; targeted mutation 2.1, University of Cologne
MGI ID: MGI:2652652
Synonyms: Ikbkbtm1.1Mpa, Ikk2D
Gene: Ikbkb  Location: Chr8:23149228-23196605 bp, - strand  Genetic Position: Chr8, 11.42 cM, cytoband A3-A4
Alliance: Ikbkbtm2.1Cgn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:77233
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA single loxP site was left in place of exons 6 and 7 after cre mediated recombination of loxP sites flanking loxP sites in the germline. Protein was undetected by Western blot analysis of MEFs and splenocytes obtained from homozygous mutant mice. (J:77233)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikbkb Mutation:  56 strains or lines available
References
Original:  J:77233 Pasparakis M, et al., TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 2002 Jun 20;417(6891):861-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory