Slpi^tm1Nkw
Targeted Allele Detail

Summary

• Symbol: Slpi^tm1Nkw
• Name: secretory leukocyte peptidase inhibitor; targeted mutation 1, Toshihiro Nukiwa
• MGI ID: MGI:2652666
• Synonyms: SLPI^-/-
• Gene: Slpi Location: Chr2:164195990-164231015 bp, - strand Genetic Position: Chr2, 85.16 cM, cytoband H
• Alliance: Slpi^tm1Nkw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82214
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of all 4 exons with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis. (J:82214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slpi Mutation: 17 strains or lines available

References

• Original: J:82214 Nakamura A, et al., Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient mice. J Exp Med. 2003 Mar 3;197(5):669-74
• All: 2 reference(s)