Lipe^tm1Gam
Targeted Allele Detail

Summary

• Symbol: Lipe^tm1Gam
• Name: lipase, hormone sensitive; targeted mutation 1, Grant A Mitchell
• MGI ID: MGI:2652711
• Synonyms: HSL^-
• Gene: Lipe Location: Chr7:25078952-25097911 bp, - strand Genetic Position: Chr7, 13.78 cM, cytoband A3
• Alliance: Lipe^tm1Gam page

Light micrographs of seminiferous tubules from wild-type and Lipe^tm1Gam/Lipe^tm1Gam mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82299
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a promoterless lacZ-neo cassette into exon 1 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analyses of adipose tissue. (J:82299)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lipe Mutation: 37 strains or lines available

References

• Original: J:82299 Wang SP, et al., The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice. Obes Res. 2001 Feb;9(2):119-28
• All: 15 reference(s)