Selenop^tm1Kohr
Targeted Allele Detail

Summary

• Symbol: Selenop^tm1Kohr
• Name: selenoprotein P; targeted mutation 1, Josef Kohrle
• MGI ID: MGI:2652747
• Synonyms: SePP-, SEPPKO
• Gene: Selenop Location: Chr15:3300249-3309992 bp, + strand Genetic Position: Chr15, 1.84 cM
• Alliance: Selenop^tm1Kohr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82244
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of the coding exons with an in-frame exon2-lacZ fusion construct and a neomycin resistance gene via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of liver and brain RNA. (J:82244)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Selenop Mutation: 24 strains or lines available

References

• Original: J:82244 Schomburg L, et al., Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem J. 2003 Mar 1;370(Pt 2):397-402
• All: 5 reference(s)