Kcnh2^tm1Hjd
Targeted Allele Detail

Summary

• Symbol: Kcnh2^tm1Hjd
• Name: potassium voltage-gated channel, subfamily H (eag-related), member 2; targeted mutation 1, Henry J Duff
• MGI ID: MGI:2652959
• Synonyms: ERG1 B^-
• Gene: Kcnh2 Location: Chr5:24524587-24556602 bp, - strand Genetic Position: Chr5, 10.94 cM
• Alliance: Kcnh2^tm1Hjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82249
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An isoform specific mutation was generated by replacing the coding region of exon 1B with a floxed neomycin selection cassette. RT-PCR analysis verified that sequence upstream of the insertion, encoding the A isoform, was transcribed. Transcript encoding the B isoform was undected in homozygous mutant mice by RT-PCR analysis. (J:82249)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnh2 Mutation: 43 strains or lines available

References

• Original: J:82249 Lees-Miller JP, et al., Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia. Mol Cell Biol. 2003 Mar;23(6):1856-62
• All: 1 reference(s)