Epas1^tm1Yfk
Targeted Allele Detail

Summary

• Symbol: Epas1^tm1Yfk
• Name: endothelial PAS domain protein 1; targeted mutation 1, Yoshiaki Fujii-Kuriyama
• MGI ID: MGI:2653011
• Synonyms: HLF^kd
• Gene: Epas1 Location: Chr17:87061292-87140838 bp, + strand Genetic Position: Chr17, 56.9 cM
• Alliance: Epas1^tm1Yfk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82257
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: The 5' UTR was disrupted by the insertion of a floxed PGK-neo cassette into exon 1 by homologous recombination. Real-time quantitative PCR analsysis of homozygous mutant mice showed reduced levels of transcript ranging from 20% to 80% of wild-type levels, depending on the organ. (J:82257)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epas1 Mutation: 66 strains or lines available

References

• Original: J:82257 Morita M, et al., HLF/HIF-2alpha is a key factor in retinopathy of prematurity in association with erythropoietin. EMBO J. 2003 Mar 3;22(5):1134-46
• All: 4 reference(s)