Cryaa^Aey7
Chemically induced Allele Detail

Summary

• Symbol: Cryaa^Aey7
• Name: crystallin, alpha A; dominant cataract 7
• MGI ID: MGI:2653028
• Synonyms: Aey7
• Gene: Cryaa Location: Chr17:31896905-31900704 bp, + strand Genetic Position: Chr17, 17.09 cM, cytoband A3-B
• Alliance: Cryaa^Aey7 page

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a T-to-A substitution at position 371 of the mRNA, which corresponds to a region in exon 3. This is predicted to cause a valine to glutamic acid replacement at codon 124. (J:72928)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cryaa Mutation: 15 strains or lines available

References

• Original: J:72928 Graw J, et al., Characterization of a new, dominant V124E mutation in the mouse alphaA-crystallin-encoding gene. Invest Ophthalmol Vis Sci. 2001 Nov;42(12):2909-15
• All: 2 reference(s)