Ndn^tm1Stw
Targeted Allele Detail

Summary

• Symbol: Ndn^tm1Stw
• Name: necdin, MAGE family member; targeted mutation 1, Colin L Stewart
• MGI ID: MGI:2653045
• Gene: Ndn Location: Chr7:61998025-61999676 bp, + strand Genetic Position: Chr7, 34.36 cM, cytoband C
• Alliance: Ndn^tm1Stw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57890
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The majority of the protein coding region of endogenous allele was replaced with a cassette containing lacZ and floxed neo. 31 5' codons were left intact. The expression pattern of lacZ differed from the expression pattern observed for Ndn^tm2Stw, which lacked the floxed neo sequence. (J:57890)

Disease models

Expression

In Mice Carrying this Mutation:	15 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndn Mutation: 18 strains or lines available

References

• Original: J:57890 Gerard M, et al., Disruption of the mouse necdin gene results in early post-natal lethality [see comments]. Nat Genet. 1999 Oct;23(2):199-202
• All: 3 reference(s)