Ndn^tm1.1Mus
Targeted Allele Detail

Summary

• Symbol: Ndn^tm1.1Mus
• Name: necdin, MAGE family member; targeted mutation 1.1, Francoise Muscatelli
• MGI ID: MGI:2653064
• Gene: Ndn Location: Chr7:61998025-61999676 bp, + strand Genetic Position: Chr7, 34.36 cM, cytoband C
• Alliance: Ndn^tm1.1Mus page

Increased apoptosis in the dorsal root ganglias of Ndn^tm1.1Mus/Ndn⁺ mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:66557
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The 5' two-thirds of the endogenous coding region was replaced with a floxed neo cassette inserted by homologous recombination. The neo cassette was then excised via cre-mediated recombination. (J:66557)

Disease models

Expression

In Mice Carrying this Mutation:	121 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndn Mutation: 18 strains or lines available

References

• Original: J:66557 Muscatelli F, et al., Disruption of the mouse necdin gene results in hypothalamic and behavioral alterations reminiscent of the human prader-willi syndrome. Hum Mol Genet. 2000 Dec 12;9(20):3101-10
• All: 10 reference(s)