Ndn^tm1Alb
Targeted Allele Detail

Summary

• Symbol: Ndn^tm1Alb
• Name: necdin, MAGE family member; targeted mutation 1, Arthur L Beaudet
• MGI ID: MGI:2653065
• Synonyms: deltaNdn, Ndn^-
• Gene: Ndn Location: Chr7:61998025-61999676 bp, + strand Genetic Position: Chr7, 34.36 cM, cytoband C
• Alliance: Ndn^tm1Alb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:55267
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A cassette containing sequence encoding beta-galactosidase and neo was inserted at the endogenous locus via homologous recombination. Transcript was undetected by Northern blot analysis of brain and liver tissue obtained from heterozygous male and female mice carrying a paternal mutant allele. (J:55267)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ndn Mutation: 18 strains or lines available

References

• Original: J:55267 Tsai TF, et al., Necdin-deficient mice do not show lethality or the obesity and infertility of Prader-Willi syndrome [letter]. Nat Genet. 1999 May;22(1):15-6
• All: 4 reference(s)