Abcc1^tm1Acs
Targeted Allele Detail

Summary

• Symbol: Abcc1^tm1Acs
• Name: ATP-binding cassette, sub-family C member 1; targeted mutation 1, Alan C Sartorelli
• MGI ID: MGI:2653091
• Synonyms: mrp(-)
• Gene: Abcc1 Location: Chr16:14179317-14292743 bp, + strand Genetic Position: Chr16, 9.75 cM
• Alliance: Abcc1^tm1Acs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:44305
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 0.7 kb genomic fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included sequence encoding a portion of the B motif of the putative ATP-binding domain. Protein was undetected by Western blot analysis of homozygous mutant mice. (J:44305)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abcc1 Mutation: 76 strains or lines available

References

• Original: J:44305 Lorico A, et al., Disruption of the murine MRP (multidrug resistance protein) gene leads to increased sensitivity to etoposide (VP-16) and increased levels of glutathione. Cancer Res. 1997 Dec 1;57(23):5238-42
• All: 12 reference(s)