Cdon^tm1Rsk
Targeted Allele Detail

Summary

• Symbol: Cdon^tm1Rsk
• Name: cell adhesion molecule-related/down-regulated by oncogenes; targeted mutation 1, Robert S Krauss
• MGI ID: MGI:2653120
• Synonyms: Cdo^-, Cdon^lacZ-1
• Gene: Cdon Location: Chr9:35332836-35418948 bp, + strand Genetic Position: Chr9, 20.24 cM
• Alliance: Cdon^tm1Rsk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82221
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was included in a 742 bp region deleted via homologous recombination. The targeting vector also contained an IRES-lacZ-neo cassette that replaced the 3' portion of exon 3. Endogenous protein was undetected by Western blot analysis of homozygous mutant mice. No beta-galactosidase activity was detected by staining. (J:82221)

Disease models

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	17 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdon Mutation: 66 strains or lines available

References

• Original: J:82221 Cole F, et al., Microform Holoprosencephaly in Mice that Lack the Ig Superfamily Member Cdon. Curr Biol. 2003 Mar 4;13(5):411-5
• All: 28 reference(s)