Areg^Mcub
Spontaneous Allele Detail

Summary

• Symbol: Areg^Mcub
• Name: amphiregulin; modifier of curly bare
• MGI ID: MGI:2653137
• Gene: Areg Location: Chr5:91287458-91296291 bp, + strand Genetic Position: Chr5, 44.78 cM
• Alliance: Areg^Mcub page

Mutation origin

• Strain of Origin: V/LeJ

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Single point mutation
• Mutation details: A T to G mutation occured in the G-GT splice donor site of exon 1 disrupting the donor site and resulting in the use of an alternative downstream splice site. The alternative splice site adds 22 nucleotides to the sequence resulting in a frame-shift and introducing a premature stop codon. Mcub is dominant modifier allele that causes a wavy coat in mice homozygous for the cub mutation. (J:211269)
• Inheritance: Dominant

Expression

In Mice Carrying this Mutation:

14 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Areg Mutation: 29 strains or lines available

References

• Original: J:82006 Johnson KR, et al., Curly bare (cub), a new mouse mutation on chromosome 11 causing skin and hair abnormalities, and a modifier gene (mcub) on chromosome 5. Genomics. 2003 Jan;81(1):6-14
• All: 7 reference(s)