Tlr3^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Tlr3^tm1Flv
• Name: toll-like receptor 3; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:2653138
• Synonyms: TLR-, Tlr3-, TLR3
• Gene: Tlr3 Location: Chr8:45848702-45864112 bp, - strand Genetic Position: Chr8, 25.31 cM, cytoband B2
• Alliance: Tlr3^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72167
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a floxed neo cassette via homologous recombination. Northern blot analysis detected a truncated transcript in mutant animals. The mutant transcript does not encode a functional protein. (J:72167)

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Tlr3 Mutation: 68 strains or lines available

References

• Original: J:72167 Alexopoulou L, et al., Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature. 2001 Oct 18;413(6857):732-8
• All: 226 reference(s)