Dspp^tm1Kul
Targeted Allele Detail

Summary

• Symbol: Dspp^tm1Kul
• Name: dentin sialophosphoprotein; targeted mutation 1, Ashok B Kulkarni
• MGI ID: MGI:2653208
• Synonyms: Dspp-
• Gene: Dspp Location: Chr5:104318578-104327993 bp, + strand Genetic Position: Chr5, 50.59 cM
• Alliance: Dspp^tm1Kul page

Tooth abnormalities in Dspp^tm1Kul/Dspp^tm1Kul mice

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84378
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 to 5 which span the entire coding region were replaced by a lacZ gene followed by a neomycin resistance gene. Lack of gene expression was established by RT-PCR and in situ hybridization. (J:84378)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dspp Mutation: 67 strains or lines available

References

• Original: J:84378 Sreenath T, et al., Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem. 2003 Jul 4;278(27):24874-80
• All: 23 reference(s)