Bfsp2^tm1Raq
Targeted Allele Detail

Summary

• Symbol: Bfsp2^tm1Raq
• Name: beaded filament structural protein 2, phakinin; targeted mutation 1, Roy A Quinlan
• MGI ID: MGI:2653265
• Synonyms: CP49^-
• Gene: Bfsp2 Location: Chr9:103302123-103357608 bp, - strand Genetic Position: Chr9, 55.37 cM
• Alliance: Bfsp2^tm1Raq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82327
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Neither endogenous transcript nor protein was identified by Northern or Western blot analyses of homozygous mutant lens tissue. (J:82327)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bfsp2 Mutation: 29 strains or lines available

References

• Original: J:82327 Sandilands A, et al., Knockout of the intermediate filament protein CP49 destabilises the lens fibre cell cytoskeleton and decreases lens optical quality, but does not induce cataract. Exp Eye Res. 2003 Mar;76(3):385-91
• All: 1 reference(s)