Cd59b^tm1Jha
Targeted Allele Detail

Summary

• Symbol: Cd59b^tm1Jha
• Name: CD59b antigen; targeted mutation 1, Jose A Halperin
• MGI ID: MGI:2653298
• Synonyms: mCd59^-, mCd59b^-
• Gene: Cd59b Location: Chr2:103900127-103920619 bp, + strand Genetic Position: Chr2, 54.51 cM
• Alliance: Cd59b^tm1Jha page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82330
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. The targeted allele was confirmed by Northern blot and RT-PCR analysis of testes RNA from homozygous mutants. (J:82330)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd59b Mutation: 11 strains or lines available

Notes

Embryonic stem cells used were derived from 129/Sv mice.

References

• Original: J:82330 Qin X, et al., Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility. Immunity. 2003 Feb;18(2):217-27
• All: 4 reference(s)