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Rr133tm1Eno
Targeted Allele Detail
Summary
Symbol: Rr133tm1Eno
Name: regulatory region 133; targeted mutation 1, Eric N Olson
MGI ID: MGI:2653307
Synonyms: BAenh-, Delta neoBAenh, Hand2BA, Hand2tm1Eno
Gene: Rr133  Location: Chr8:57767577-57768385 bp  Genetic Position: Chr8, Syntenic
Alliance: Rr133tm1Eno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:81764
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA 754 bp region, containing the 208 bp branchial arch enhancer upstream of the Hand2 gene, was replaced with a loxP site flanked neomycin resistance gene cassette, which was removed through subsequent cre-mediated recombination. Whole mount in situ hybridization of homozygous mutant embryos showed a lack of endogenous transcript in the ventrolateral portions of the first and second branchial arches. (J:81764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 13 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr133 Mutation:  0 strains or lines available
References
Original:  J:81764 Yanagisawa H, et al., Targeted deletion of a branchial arch-specific enhancer reveals a role of dHAND in craniofacial development. Development. 2003 Mar;130(6):1069-78
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory